by Charlie Smith | Sep 19, 2020 | Science Highlights - BioCARS
Direct observation of functional motions in protein structures is highly desirable for understanding how these nanomachineries of life operate at the molecular level. Because cryogenic temperatures are non-physiological and may prohibit or even alter protein...
by Charlie Smith | Feb 6, 2020 | Science Highlights - BioCARS
Small molecules such as molecular oxygen, nitric oxide, and carbon monoxide play important roles in life, and many proteins require the transport of small molecules to and from the bulk solvent for their function. Ligand migration within a protein molecule is expected...
by Charlie Smith | Feb 4, 2020 | Science Highlights - BioCARS
Correlated motions of proteins are critical to function, but these features are difficult to resolve using traditional structure determination techniques. Time-resolved X-ray methods hold promise for addressing this challenge, but have relied on the exploitation of...
by Charlie Smith | May 1, 2019 | Science Highlights - BioCARS
Since the first successful serial crystallography (SX) experiment at a synchrotron radiation source, the popularity of this approach has continued to grow showing that third-generation synchrotrons can be viable alternatives to scarce X-ray free-electron laser...
