Taming the Chlorine Radical: Enforcing Steric Control over Chlorine-Radical-Mediated C−H Activation

J. Am. Chem. Soc. 2022, 144, 1464−1472

Researchers from Harvard University and the University of Chicago stuied the C−H functionalization reactions. They used photocrystallography to confirm that this selectivity arises from the generation of Cl· within the steric environment defined by the iron secondary coordination sphere.

DOI: 10.1021/jacs.1c13333

https://pubs.acs.org/doi/10.1021/jacs.1c13333