Time-resolved solution scattering studies of a homodimeric hemoglobin conducted at BioCARS 14-ID beamline linked the perturbation in the water cluster at the dimer interface to the kinetics and structures of intermediate states in this hemoglobin.
Kim, J. G., Muniyappan, S., Oang, K. Y., Kim, T. W., Yang, C., Kim, K. H., Kim, J., and Ihee, H. Cooperative protein structural dynamics of homodimeric hemoglobin linked to water cluster at subunit interface revealed by time-resolved X-ray solution scattering. Structural Dynamics 3, 023610 (2016) abstract